Many times restlessness in the legs can be an uncomfortable condition that can interrupt sleep patterns and keep one from getting vital rest and downtime. It’s often a small sensation that is felt often in the calves and only brought on when lying down or about to go to sleep. Periods of inactivity such as long car drives or sitting in a theatre or on long haul flights can also bring on the sensation. Pregnancy can also be a precursor to the sensation and this is directly involved with the indications of Iron levels (see below). Some medications can also bring on the symptoms particularly those associated with antidepressants, antipsychotics, antihistamines and calcium channel blockers.